Profiling multiple omic layers in a single cell enables the discovery and analysis of biological
phenomena that are not apparent from analysis of mono‐omic data. While methods for …

How distinct transcriptional programs are enacted to generate cellular heterogeneity and
plasticity, and enable complex fate decisions are important open questions. One key …

Technical advances have enabled the collection of genome and transcriptome data sets
with single-cell resolution. However, single-cell characterization of the epigenome has …

A growing number of single-cell sequencing platforms enable joint profiling of multiple omics
from the same cells. We present Cobolt, a novel method that not only allows for analyzing …

Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

The advent of single-cell chromatin accessibility profiling has accelerated the ability to map
gene regulatory landscapes but has outpaced the development of scalable software to …

Single cell high throughput genomic measurements are revolutionizing the fields of biology
and medicine, providing a means to tackle biological problems that have thus far been …

Joint profiling of transcriptome and chromatin accessibility within single cells allows for the
deconstruction of the complex relationship between transcriptional states and upstream …