A modular template for the design of thiol-triggered sensors and prodrugs

JR Knight, Y Wang, S Xu, W Chen, CE Berkman… - … Acta Part A: Molecular …, 2021 - Elsevier
A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered.
This reaction was specific for thiols and produced a sulfinic acid (RSO 2 H) as the …

Benzothiazole-Derived Sulfones and Sulfoxides as Reactive Templates for Biothiols and Sulfane Sulfurs

S Xu, JR Knight, BJ Brummett, M Shieh, Q Cui… - Organic …, 2022 - ACS Publications
In this work we studied the reactions of benzothiazole sulfones and sulfoxides toward
reactive sulfur species. The reaction of thiols with benzothiazole sulfones produces sulfinic …

Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells

X Li, S Qian, Q He, B Yang, J Li, Y Hu - Organic & biomolecular …, 2010 - pubs.rsc.org
A new fluorescent turn-on probe for the rapid optical sensing of thiols has been designed
and synthesized. The probe displays high on/off signal ratios and high selectivity towards …

A new fluorescent 'turn on'probe for rapid detection of biothiols

M Üçüncü, H Zeybek, E Karakuş, C Üçüncü… - Supramolecular …, 2020 - Taylor & Francis
We designed and synthesised a novel molecular probe exhibiting high selectivity and
sensitivity towards reactive sulphur species (RSS) over other amino acids and biologically …

A thiol–thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

C Ge, H Wang, B Zhang, J Yao, X Li, W Feng… - Chemical …, 2015 - pubs.rsc.org
The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol
recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity …

Thiol reactive probes and chemosensors

H Peng, W Chen, Y Cheng, L Hakuna, R Strongin… - Sensors, 2012 - mdpi.com
Thiols are important molecules in the environment and in biological processes. Cysteine
(Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) play critical roles …

Disulfide-cleavage-triggered chemosensors and their biological applications

MH Lee, Z Yang, CW Lim, YH Lee, S Dongbang… - Chemical …, 2013 - ACS Publications
The disulfide bond (− S− S−) is an extremely valuable functional group in a variety of
chemical and biological agents that display potent reactivity or biological activities (eg …

A turn-on green fluorescent thiol probe based on the 1, 2-addition reaction and its application for bioimaging

F Huo, J Kang, C Yin, Y Zhang, J Chao - Sensors and Actuators B …, 2015 - Elsevier
The nucleophilic nature of thiols is used to develop a novel, sensitive, and highly effective
sensor. In this work, we developed a new fluorescent probe for thiols based on fluorescein …

A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups

H Zhang, C Zhang, R Liu, L Yi, H Sun - Chemical Communications, 2015 - pubs.rsc.org
A new fluorescent probe installed with dual-reactive and dual-quenching groups was
rationally designed for highly selective and sensitive sensing of biothiols. The sensitivity of …

An Iminocoumarin sulfonamide based turn‐On fluorescent probe for the Detection of biothiols in aqueous solution

YL Yang, FM Zhang, YW Wang… - Chemistry–An Asian …, 2015 - Wiley Online Library
A new chemodosimeter for the highly selective sensing and imaging of biothiols was
designed and realized in phosphate‐buffered saline solution at pH 7.4 through a …