Metallo-β-lactamases (MBLs) confer antibiotic resistance to bacteria by hydrolyzing and thus
inactivating β-lactam antibiotics. They have raised concerns due to their broad substrate …

The emergence of antibiotic resistance caused by metallo-β-lactamases (MβLs) is a global
public health problem. Recently, we found amino acid thioesters to be a highly promising …

The inhibition of metallo-β-lactamases (MBL) can prevent the hydrolysis of β-lactam
antibiotics and hence is a promising strategy for the treatment of antibiotic resistant …

The production of metallo-β-lactamases is the most important strategy by which pathogenic
bacteria become resistant to currently known β-lactam antibiotics. The emergence of these …

The increasing number of pathogens expressing metallo-β-lactamases (MBLs), and in this
way achieving resistance to β-lactam antibiotics, is a significant threat to global public …

ABSTRACT A novel subclass B3 metallo-β-lactamase (MBL), SMB-1, recently identified from
a Serratia marcescens clinical isolate, showed a higher hydrolytic activity against a wide …

Abstract Metallo-β-lactamases (MBLs) represent one of the most important and widespread
mechanisms of resistance to β-lactam antibiotics (including the life-saving carbapenems) …

Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major
public health threat. Zn (II)-dependent or metallo-β-lactamases (MBLs) produced by these …

Sir, b-Lactams are the most widely employed antibiotics with their successful use in the
treatment of infectious diseases being well documented for many years. 1 Bacterial …

Pathogenic bacteria that produce metallo-b-lactamases (MBLs) are emerging as a new
challenge to the medical community. These enzymes catalyze the hydrolysis of a wide …