[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe… - Immunity, 2021 - cell.com
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

G Leem, S Cheon, H Lee, SJ Choi, S Jeong… - Journal of Allergy and …, 2021 - Elsevier
Background Our understanding of adaptive immune responses in patients with coronavirus
disease 2019 (COVID-19) is rapidly evolving, but information on the innate immune …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

[HTML][HTML] Cell-type-specific immune dysregulation in severely ill COVID-19 patients

C Yao, SA Bora, T Parimon, T Zaman, OA Friedman… - Cell reports, 2021 - cell.com
Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

B Malengier-Devlies, J Filtjens, K Ahmadzadeh… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here …

Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound NKT cell impairment

J Liu, X Yang, H Wang, Z Li, H Deng, J Liu, S Xiong… - MBio, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected over 120 million people …

Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease …

F Bozzano, C Dentone, C Perrone, A Di Biagio… - PLoS …, 2021 - journals.plos.org
The SARS-CoV-2 infection causes severe respiratory involvement (COVID-19) in 5–20% of
patients through initial immune derangement, followed by intense cytokine production and …

Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression

AF Rendeiro, J Casano, CK Vorkas… - Life science …, 2021 - life-science-alliance.org
With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is
critical to elucidate the innate and adaptive immune responses that drive disease severity …