[HTML][HTML] Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants

J Lu, Q Yin, R Pei, Q Zhang, Y Qu, Y Pan, L Sun, D Gao… - Virologica Sinica, 2022 - Elsevier
Multiple new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have constantly emerged, as the delta and omicron variants, which have developed …

Nasal spray of neutralizing monoclonal antibody 35B5 confers potential prophylaxis against severe acute respiratory syndrome coronavirus 2 variants of concern: a …

Y Lin, S Yue, Y Yang, S Yang, Z Pan… - Clinical Infectious …, 2023 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of
concern (VOCs), especially the Delta and Omicron variants, have been reported to show …

A potent and protective human neutralizing antibody against SARS-CoV-2 variants

S Shan, CK Mok, S Zhang, J Lan, J Li, Z Yang… - Frontiers in …, 2021 - frontiersin.org
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge and spread around the world, antibodies and vaccines to confer broad and potent …

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron …

X Li, Y Pan, Q Yin, Z Wang, S Shan, L Zhang, J Yu… - Cell discovery, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
(VOCs), especially the latest Omicron, have exhibited severe antibody evasion. Broadly …

Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants

C Boonkrai, TS Cotrone, W Chaisuriyong… - Plos one, 2023 - journals.plos.org
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
currently the biggest healthcare issue worldwide. This study aimed to develop a monoclonal …

Augmented neutralization of SARS‐CoV‐2 Omicron variant by boost vaccination and monoclonal antibodies

SR Schulz, M Hoffmann, E Roth… - European Journal of …, 2022 - Wiley Online Library
Effective vaccines and monoclonal antibodies have been developed against coronavirus
disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 …

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

K Murano, Y Guo, H Siomi - Biochemical Society Transactions, 2021 - portlandpress.com
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of the coronavirus disease (COVID-19) pandemic. As of August 2021, more than …

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

X Zhang, H Zhang, T Li, S Chen, F Luo… - Signal transduction and …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still rapidly spreading
worldwide. Many drugs and vaccines have been approved for clinical use show efficacy in …

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

S Changrob, PJ Halfmann, H Liu… - The Journal of …, 2023 - Am Soc Clin Investig
The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variants has emphasized the need to identify antibodies with broad neutralizing …

Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails

H Ma, H Zong, J Liu, Y Yue, Y Ke, Y Liao… - Acta Pharmacologica …, 2023 - nature.com
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants poses challenges to the effectiveness of neutralizing antibodies. Rational design …