NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and
transformed cells, being one of the main executors of cell death in the immune system. NK …

After recognition, NK cells can kill susceptible target cells through perforin-dependent
mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete …

NK cells are innate lymphoid cells that exert a key role in immune surveillance through the
recognition and elimination of transformed cells and viral, bacterial, and protozoan pathogen …

Natural killer (NK) cells kill mutant cells through death receptors and cytotoxic granules,
playing an essential role in controlling cancer progression. However, in the tumor …

Apoptotic cell death is initiated by a morphologically homogenous entity that was considered
to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest …

Natural killer cells are important effector lymphocytes of the innate immune system, playing
critical roles in antitumor and anti-infection host defense. Tumor progression or chronic …

Immune checkpoint receptors (IC) positively or negatively regulate the activation of the host
immune response, preventing unwanted reactions against self-healthy tissues. In recent …

Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

Immune therapy of cancer is among the most promising recent advances in medicine.
Whether the immune system can keep cancer in check depends on, among other factors, the …

In this review, we overview the main features and functions of NK cells, focusing on their role
in cell-mediated immune response to tumor cells. In parallel, we discuss the information …