A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury

ZX Zhang, LX Guan, K Zhang, Q Zhang, LJ Dai - Cytotherapy, 2008 - Elsevier
Background There is increasing evidence of therapeutic benefits from bone marrow (BM)-
derived mesenchymal stromal cells (MSC) in various animal models with neurologic …

Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain

A Mahmood, D Lu, M Chopp - Neurosurgery, 2004 - journals.lww.com
OBJECTIVE: This study was designed to investigate the effects of intracerebral as well as
intravenous administration of bone marrow stromal cells (MSCs) on endogenous cellular …

Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells

A Mahmood, D Lu, M Lu, M Chopp - Neurosurgery, 2003 - journals.lww.com
OBJECTIVE We investigated the effect of human bone marrow stromal cells (hMSCs)
administered intravenously on functional outcome after traumatic brain injury in adult rats …

Human marrow stromal cell treatment provides long-lasting benefit after traumatic brain injury in rats

A Mahmood, D Lu, C Qu, A Goussev, M Chopp - Neurosurgery, 2005 - journals.lww.com
OBJECTIVE: This study was designed to investigate the effects of human bone marrow
stromal cell (hMSC) administration in rats for 3 months after traumatic brain injury (TBI) …

Marrow stromal cell transplantation in stroke and traumatic brain injury

Y Li, M Chopp - Neuroscience letters, 2009 - Elsevier
There is a paucity of therapies for most central nervous system (CNS) disorders. Bone
marrow stromal cells (MSCs) are a mixed cell population, including stem and progenitor …

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

AM Parr, CH Tator, A Keating - Bone marrow transplantation, 2007 - nature.com
Transplantation of bone marrow-derived mesenchymal stromal cells (MSCs) into the injured
brain or spinal cord may provide therapeutic benefit. Several models of central nervous …

Treatment of traumatic brain injury in mice with marrow stromal cells

C Qu, A Mahmood, D Lu, A Goussev, Y Xiong… - Brain research, 2008 - Elsevier
This study was designed to investigate the potential beneficial effects of bone marrow
stromal cell (MSC) treatment of traumatic brain injury (TBI) in mice. Twelve female C57BL/6J …

Intravenous mesenchymal stem cell therapy for traumatic brain injury

MT Harting, F Jimenez, H Xue, UM Fischer… - Journal of …, 2009 - thejns.org
Object Cell therapy has shown preclinical promise in the treatment of many diseases, and its
application is being translated to the clinical arena. Intravenous mesenchymal stem cell …

The therapeutic effects of cellular therapy for functional recovery after brain injury

RL Harvey, M Chopp - Physical Medicine and Rehabilitation …, 2003 - pmr.theclinics.com
There has been a growing interest in the use of stem cells in medical treatment because of
their capacity to generate cell types into multiple lineages, including neural tissue [1]. Neural …

Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats

J Wu, Z Sun, HS Sun, J Wu, RD Weisel… - Cell …, 2007 - journals.sagepub.com
Accumulated evidence suggests that bone marrow stromal cells (BMSCs) are capable of
regenerating damaged tissue. This study evaluated whether intravenously (noninvasively) …