The air-blood barrier with its complex architecture and dynamic environment is difficult to
mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin …

We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment,
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …

Here we describe a microphysiological system that replicates the functional unit of the living
human lung. This human “breathing lung-on-a-chip” microdevice provides unique …

Chronic respiratory diseases are among the leading causes of death worldwide, but only
symptomatic therapies are available for terminal illness. This in part reflects a lack of …

Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …

Organs-on-chips have the potential to improve drug development efficiency and decrease
the need for animal testing. For the successful integration of these devices in research and …

The lung alveolar region experiences remodeling during several acute and chronic lung
diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease, whose onset is …

Abstract'Organs-on-chips' are microengineered biomimetic systems containing microfluidic
channels lined by living human cells, which replicate key functional units of living organs to …

There is an urgent need for physiologically relevant and customizable biochip models of
human lung tissue to provide a niche for lung disease modeling and drug efficacy. Although …

Lung‐on‐a‐chip models hold great promise for disease modeling and drug screening.
Herein, inspired by the iridescence phenomenon of soap bubbles, a novel biomimetic 3D …