Drug candidates with one or more fluorines have become commonplace. The special nature
of fluorine imparts a variety of properties to certain medicines, including enhanced binding …

It has become evident that fluorinated compounds have a remarkable record in medicinal
chemistry and will play a continuing role in providing lead compounds for therapeutic …

Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal
chemistry has become commonplace, with the small electronegative fluorine atom being a …

Advances in the development of newly developed fluorinated drugs, approved or in clinical
trials, as organized by biological targets/disease states, are reviewed. In a few cases …

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and
chemical biology has been recognized by researchers outside of the traditional fluorine …

Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Methods for introducing fluorine into organic molecules are reviewed, with an emphasis on
preparation of compounds designed for biomedicinal applications. Electrophilic fluorination …

Introduction: The pivotal role that the element fluorine plays in modulating the properties of
bioactive molecules is reflected by the growth of its presence in approved drugs. In 1970 …

Organic fluorine compounds have had a profound impact on the development of bioactives
for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals …

Introduction: Fluorine's unique physicochemical properties make it a key element for
incorporation into pharmacologically active compounds. Its presence in a drug can alter a …