Background Although immune modulation is a promising therapeutic avenue in coronavirus
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …

Although it has been more than 2 years since the start of the coronavirus disease 2019
(COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the …

Background Excessive monocyte/macrophage activation with the development of a cytokine
storm and subsequent acute lung injury, leading to acute respiratory distress syndrome …

Mononuclear phagocytes are a widely distributed family of cells contributing to innate and
adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages …

Abstract The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and
affected millions of people around the globe. As of January 2021, 100 million confirmed …

The Coronavirus Disease 2019 (COVID-19) is caused by the betacoronavirus Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus that can mediate asymptomatic or …

To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

Despite the worldwide effect of the coronavirus disease 2019 (COVID-19) pandemic, the
underlying mechanisms of fatal viral pneumonia remain elusive. Here, we show that critical …

Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …

Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …