Substrate-specific structural rearrangements of human Dicer
DW Taylor, E Ma, H Shigematsu… - Nature structural & …, 2013 - nature.com
Dicer has a central role in RNA-interference pathways by cleaving double-stranded RNAs
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
(dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double …
Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids
WF Lima, H Murray, JG Nichols, H Wu, H Sun… - Journal of biological …, 2009 - ASBMB
Human Dicer is an integral component of the RNA interference pathway. Dicer processes
premicro-RNA and double-strand RNA to, respectively, mature micro-RNA and short …
premicro-RNA and double-strand RNA to, respectively, mature micro-RNA and short …
[HTML][HTML] Coordinated activities of human dicer domains in regulatory RNA processing
The conserved ribonuclease Dicer generates microRNAs and short‐interfering RNAs that
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
guide gene silencing in eukaryotes. The specific contributions of human Dicer's structural …
Production of small RNAs by mammalian Dicer
E Svobodova, J Kubikova, P Svoboda - Pflügers Archiv-European Journal …, 2016 - Springer
MicroRNA (miRNA) and RNA interference (RNAi) pathways employ RNase III Dicer for the
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …
[HTML][HTML] Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
H Zhang, FA Kolb, V Brondani, E Billy… - The EMBO …, 2002 - embopress.org
Dicer is a multi‐domain RNase III‐related endonuclease responsible for processing double‐
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
stranded RNA (dsRNA) to small interfering RNAs (siRNAs) during a process of RNA …
Structural determinants of RNA recognition and cleavage by Dicer
A hallmark of RNA interference is the production of short double-stranded RNA (dsRNA)
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …
molecules 21–28 nucleotides in length by the specialized RNase III protein Dicer. Dicer …
Substrate-specific kinetics of Dicer-catalyzed RNA processing
S Chakravarthy, SH Sternberg, CA Kellenberger… - Journal of molecular …, 2010 - Elsevier
The specialized ribonuclease Dicer plays a central role in eukaryotic gene expression by
producing small regulatory RNAs—microRNAs (miRNAs) and short interfering RNAs …
producing small regulatory RNAs—microRNAs (miRNAs) and short interfering RNAs …
Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage
Dicer, an RNase III enzyme, initiates RNA interference by processing precursor dsRNAs into
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …
mature microRNAs and small-interfering RNAs. It is also involved in loading and activation …
The role of human Dicer-dsRBD in processing small regulatory RNAs
One of the most exciting recent developments in RNA biology has been the discovery of
small non-coding RNAs that affect gene expression through the RNA interference (RNAi) …
small non-coding RNAs that affect gene expression through the RNA interference (RNAi) …
Dicer structure and function: conserved and evolving features
D Zapletal, K Kubicek, P Svoboda, R Stefl - EMBO reports, 2023 - embopress.org
RNase III Dicer produces small RNAs guiding sequence‐specific regulations, with important
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …