Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the
expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p …

Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early
hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact …

Murine dendritic cells (DCs) can be classified into at least 2 subsets,“myeloid-
related”(CD11bbright, CD8α−) and “lymphoid-related”(CD11bdull, CD8α+), but the absolute …

The dendritic cell system contains conventional dendritic cells (DCs) and plasmacytoid pre-
dendritic cells (pDCs). Both DCs and pDCs are bone marrow derived cells. Although the …

Using a recently described serum-free culture system of purified human CD34+ progenitor
cells, we show here a critical cooperation of flt3 ligand (FL) with transforming growth factor …

Plasmacytoid predendritic cells or type 1 interferon (IFN)-producing cells (IPCs) have
recently been identified in mice. Although culture systems giving rise to different murine …

FLT3 ligand (FL) is a recently described hematopoietic growth factor that stimulates the
proliferation and differentiation of hematopoietic progenitors. We have investigated the effect …

Dendritic cell (DC) development begins in the bone marrow but is not completed until after
immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic …

We established a humanized mouse model incorporating FLT3-ligand (FLT3-L)
administration after hematopoietic cell reconstitution to investigate expansion, phenotype …

Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and
functions exist in mouse and human. The two subsets of cDCs are specialized antigen …