Background Multiple processes have been implicated in age-related delayed healing,
including altered gene expression, intrinsic cellular changes, and changes in extracellular …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

Increasing evidence indicates that chronic inflammation and senescence are the cause of
many severe age-related diseases, with both biological processes highly upregulated …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Background Skin aging is associated with intrinsic processes that compromise the structure
of the extracellular matrix while promoting loss of functional and regenerative capacity …

A key goal of aging research was to understand mechanisms underlying healthy aging and
develop methods to promote the human healthspan. One approach is to identify gene …

Aging is a complex process that can be characterized by functional and cognitive decline in
an individual. Aging can be assessed based on the functional capacity of vital organs and …

Senescent cells have detrimental effects across tissues with aging but may have beneficial
effects on tissue repair, specifically on skin wound healing. However, the potential role of …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Background: Limited replicative capacity is a defining characteristic of most normal human
cells and culminates in senescence, an arrested state in which cells remain viable but …