The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Dysregulation of the dopamine system is central to many models of the pathophysiology of
psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …

Despite evidence for a role of the dopamine system in the pathophysiology of schizophrenia,
there has not been substantial evidence that this disorder originates from a pathological …

After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …

The stagnation in drug development for schizophrenia highlights the need for better
translation between basic and clinical research. Understanding the neurobiology of …

Schizophrenia is a disease of abnormal brain development. Considerable evidence now
indicates that environmental factors have a causative role in schizophrenia. Elevated …

Schizophrenia and related mental disorders are common and devastating conditions for
which we have a limited understanding of their origin and mechanisms. Although this …