Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To …

Human embryonic stem cells (hESCs) share an identical genome with lineage-committed
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …

Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …

Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to
differentiate into functionally distinct cell types. ES cells proliferate and differentiate without …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Epigenetic mechanisms, such as histone modifications and DNA methylation, have been
shown to play a key role in the regulation of gene transcription. Results of recent studies …

Embryonic (ES) and epiblast (EpiSC) stem cells are pluripotent but committed to an
embryonic lineage fate. Conversely, trophoblast (TS) and extraembryonic endoderm (XEN) …

Background Human pluripotent stem cells offer the best available model to study the
underlying cellular and molecular mechanisms of human embryonic lineage specification …

The molecular mechanisms underlying pluripotency and lineage specification from
embryonic stem cells (ESCs) are still largely unclear. To address the role of chromatin …

Human embryonic stem cells (hESCs) typically exhibit" primed" pluripotency, analogous to
stem cells derived from the mouse post-implantation epiblast. This has led to a search for …