ABSTRACT Background: The K3326X variant in BRCA2 (BRCA2* c. 9976A> T; p. Lys3326*;
rs11571833) has been found to be associated with small increased risks of breast cancer …

Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A
rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a …

Background Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary
breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326*(rs11571833) …

The breast cancer predisposition gene, BRCA2, has a large number of genetic variants of
unknown effect. The variant rs11571833, an A> T transversion in the final exon of the gene …

Variants of uncertain clinical significance (VUS) in the high-penetrance breast cancer
susceptibility genes BRCA1 and BRCA2 represent a major obstacle in genetic counseling of …

Although the spliceogenic nature of the BRCA2 c. 68‐7T> A variant has been demonstrated,
its association with cancer risk remains controversial. In this study, we accurately quantified …

Abstract Background: The K3326X variant in BRCA2 (BRCA2* c. 9976A> T; p. Lys3326*;
rs11571833) has been found to be associated with small increased risks of breast cancer …

Purpose Whereas lung cancer incidence among men has declined in recent years, the
incidence rate among women has increased rapidly. Sex could affect DNA repair capacity …

Mutation screening of the breast and ovarian cancer predisposition genes BRCA1 and
BRCA2 is becoming an increasingly important part of clinical practice. Classification of rare …

Simple Summary The potential pathogenic role of germline BRCA2 c. 9976A> T and c.
10095delinsGAATTATATCT was evaluated in hereditary breast and ovarian cancer (HBOC) …