Within nucleosomes, canonical histones package the genome, but they can be opportunely
replaced with histone variants. The incorporation of histone variants into the nucleosome is …

Isolated cases of experimental evidence over the last few decades have shown that, where
specifically tested, both prokaryotes and eukaryotes have specific lipid species bound to …

Structural changes in chromatin regulate gene expression and define phenotypic outcomes.
Molecules that bind to the nucleosome, the complex of DNA and histone proteins, are key …

Abstract The World Health Organization (WHO) has identified the obesity epidemic as one of
the leading causes of overall morbidity and mortality. Obesity affects individual health, and …

Histone variant are non-allelic forms of the conventional histones. They are expressed at
very low levels compared to their conventional counterparts. All the conventional histones …

Epigenetic modifications on chromatin are most commonly thought to be involved in the
transcriptional regulation of gene expression. Due to their dependency on small-molecule …

Histone modifications and their modifying enzymes are fundamentally involved in the
epigenetic regulation of adipogenesis. This study aimed to define the roles of various …

Epigenetic changes related to human disease cannot be fully addressed by studies of cells
from cultures or from other mammals. We isolated human fat cells from subcutaneous …

The nuclear lipid fraction is comprised of glycerophospholipids, sphingolipids,
plasmalogens, gangliosides, cholesterol and fatty acids. Intranuclear lipid enzymes are …

A number of recent studies revealed that epigenetic modifications play a central role in the
regulation of lipid and of other metabolic pathways such as cholesterol homeostasis, bile …