A Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) inhibitor that is potent
(KI= 15 nM) and species-selective (> 5000-fold over the human enzyme) was identified by …

Malaria puts at risk nearly half the world's population and causes high mortality in sub-
Saharan Africa, while drug resistance threatens current therapies. The pyrimidine …

In the search of new antiplasmodial agents, a multitargeted approach was used in the
synthesis of triazolopyrimidine-and 4-aminoquinolines-based hybrids. In vitro antiplasmodial …

A class of hybrid molecules consisting of 4-aminoquinoline and pyrimidine were synthesized
and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and …

The control of malaria is challenged by drug resistance, and new antimalarial drugs are
needed. New drug discovery efforts include consideration of hybrid compounds as potential …

The control of malaria has been complicated with increasing resistance of malarial parasite
against existing antimalarials. Herein, we report the synthesis of a new series of chloroquine …

Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs,
chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for …

In response to the malaria parasite's resistance towards quinoline-based antimalarial drugs,
we have employed quinoline-containing compounds in combination with …

We report on the design, synthesis, and in vitro evaluation of new quinoline-5, 8-dione and
hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro …

Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability
to maintain effective therapy to combat the illness is continually challenged by the …