The emergence and rapid spread of chloroquine resistant strains of Plasmodium falciparum
has dramatically reduced the chemotherapeutic options. Towards this goal, a series of new …

The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of
1, 1, 1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been …

From the promising results we previously obtained in quinazoline series and to complete the
evaluation of the in vitro antiplasmodial activity of original 2-trichloromethylquinazolines, we …

Malaria persists as one of the most devastating global infectious diseases. The pyrimidine
biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new …

Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

The multistep synthesis of new quinazoline-derived molecules and their in vitro
antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is …

Readily accessible, novel, and potent anti-malarial compounds have been developed.
Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Novel 5-substituted amino-2, 4-diamino-8-chloropyrimido-[4, 5-b] quinolines were designed
based on a pharmacophore developed for potent antimalarial activity using Chem-X and …