A series of new 21 chloroquine heterocyclic hybrids containing either benzylamino fragment
or N-(aminoalkyl) thiazolidin-4-one moiety were synthesized and screened for their …

Introduction Pyrimidine nucleotides are essential for the parasite's growth and replication.
Parasites have only a de novo pathway for the biosynthesis of pyrimidine nucleotides …

We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …

Emergence and spread of multidrug resistant strains of Plasmodium falciparum has severely
limited the antimalarial chemotherapeutic options. In order to overcome the obstacle, a set of …

The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to
evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought …

For the treatment of malaria which affects nearly 200 million people each year and the
continued exacerbation by the emergence of drug resistance to most of the available …

Both the lack of a credible malaria vaccine and the emergence and spread of parasites
resistant to most of the clinically used antimalarial drugs and drug combination have …

New drugs to treat malaria must act rapidly and be highly potent against asexual blood
stages, well tolerated, and affordable to residents of regions of endemicity. This was the …

Despite the recent reductions in the global burden of malaria, this disease remains a
devastating cause of death in tropical and subtropical regions. As there is no broadly …

Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs
are urgently required at an affordable price. We report herein the design, synthesis, and …