A series of original quinazolines bearing a 4-thiophenoxy and a 2-trichloromethyl group was
synthesized in a convenient and efficient way and was evaluated toward its in vitro …

Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially
represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step …

For several decades, the 4-aminoquinolines chloroquine (CQ) and amodiaquine (AQ) were
considered the most important drugs for the control and eradication of malaria. The success …

A series of novel tetrazole derivatives of 4-aminoquinoline were synthesized and screened
for their antimalarial activities against both chloroquine-senstive (3D7) and chloroquine …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

We report herein synthesis of a series of 4‐aminoquinoline‐1, 2, 3‐triazole and 4‐
aminoquinoline‐1, 2, 3‐triazole‐1, 3, 5‐triazine hybrids and evaluate their antimalarial …

Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates
having fallen by 47% since 2000. While the World Health Organization (WHO) recommends …

Chloroquine (CQ) is a safe and economical 4-aminoquinoline (AQ) antimalarial. However,
its value has been severely compromised by the increasing prevalence of CQ resistance …

Malaria with 1 million deaths and about 500 million new cases reported annually is a
challenge to drug therapy and discovery. Drug resistance accompanied by lack of progress …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …