Three series of monoquinolines consisting of a 1, 4-bis (3-aminopropyl) piperazine linker
and a large variety of terminal groups were synthesized. Our aim was to prove that in related …

Abstract Using 2, 8-bis (trifluoromethyl) quinoline, the pharmacophore of mefloquine, as
scaffold, eleven novel triazole-linked compounds have been synthesised by the application …

Plasmodium falciparum causes approximately 1 million deaths annually. However,
increasing resistance imposes a continuous threat to existing drug therapies. We previously …

Novel antimalarial therapeutics that target multiple stages of the parasite lifecycle are
urgently required to tackle the emerging problem of resistance with current drugs. Here, we …

A series of pyrazole-pyrazoline substituted with benzenesulfonamide were synthesized and
evaluated for their antimalarial activity in vitro and in vivo. The compounds were active …

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-
carboxamides are described. This series was identified from a phenotypic screen against …

Despite emergence of resistance to CQ and other 4-aminoquinoline drugs in most of the
endemic regions, research findings provide considerable support that there is still significant …

A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was
synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach …

Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or
therapeutic index). However, CQ is no longer used alone to treat patients with Plasmodium …