Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) has been clinically
validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor …

Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine
biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of …

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-
hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth …

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of
Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant …

Emergence of drug resistance and targeting all stages of the parasite life cycle are currently
the major challenges in antimalarial chemotherapy. Molecular hybridization combining two …

Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as
antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to …

A systematic chemical modification in the triazine moiety covalently attached via suitable
linkers to 4‐amino‐7‐chloroquinolines yielded a series of new 7‐chloro‐4‐aminoquinoline …

To identify a new safe antiplasmodial molecular scaffold, an original series of 2-
trichloromethylquinazolines, functionalized in position 4 by an alkyl-or arylamino substituent …

Pyrimidine biosynthesis presents an attractive drug target in malaria parasites due to the
absence of a pyrimidine salvage pathway. A set of compounds designed to inhibit the …

According to the World Health Organization, half of the World's population, approximately
3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are …