According to the World Health Organization, half of the World's population, approximately
3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are …

From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we
conducted a global Structure-Activity relationship (SAR) study involving 26 compounds and …

As part of our medicinal chemistry program's ongoing search for compounds with
antimalarial activity, we prepared a series of thiazole analogs and conducted a SAR study …

As a continuation of our research and with the aim of obtaining new antimalarial agents, new
series of 3-phenylquinoxaline 1, 4-di-N-oxide derivatives have been synthesized following …

Plasmodium falciparum causes 1− 2 million deaths annually. Yet current drug therapies are
compromised by resistance. We previously described potent and selective …

Abstract New 1, 3, 4-trisubstituted pyrazole derivatives were synthesized and evaluated for
their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent …

2-Aminopyrimidine based 4-aminoquinolines were synthesized using an efficacious
protocol. Some of the compounds showed in vitro anti-plasmodial activity against drug …

A series of noncytotoxic 4-aminoquinoline-3-hydroxypyridin-4-one hybrids were synthesized
on the basis of a synergistic in vitro combination of a precursor N-alkyl-3-hydroxypyridin-4 …

Taking the emergence of drug resistance and lack of effective antimalarial vaccines into
consideration, it is of significant importance to develop novel antimalarial agents for the …

In the search of novel chemotherapeutic agents for emerging drug resistant parasites, the
hybridization approaches have successfully emerged as an efficient tool in malarial …