Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD)
patients. A part of the dietary protein-derived tryptophan is metabolized into indole by …

Indoxyl sulfate, a nephrovascular uremic toxin, is markedly accumulated in the serum of
chronic kidney disease (CKD) patients. Because of its protein binding ability, its removal by …

BACKGROUND AND AIMS: Indoxyl sulfate, a protein-bound uremic toxin, was found to be
accumulated in kidney tissues with a reduction in renal function. This, in turn, not only leads …

To determine the role of indoxyl sulfate in the progression of glomerular sclerosis, the serum
level of indoxyl sulfate was measured in patients with uremia, and the effect of oral …

Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with
declining kidney function. Although generally thought of as a consequence of declining …

Indoxyl sulfate is markedly accumulated in the serum of patients with chronic kidney disease
(CKD). The oral sorbent AST-120 reduces the serum levels of indoxyl sulfate in CKD …

Background: Indoxyl sulfate is a uremic toxin that accelerates the progression of chronic
kidney disease (CKD). Serum levels of indoxyl sulfate are increased in dialysis patients. It …

Indoxyl sulfate is an extensively studied uremic solute. It is a small molecule that is more
than 90% bound to plasma proteins. Indoxyl sulfate is derived from the breakdown of …

Several abnormalities of the cardiovascular system are observed in most cases of chronic
kidney disease (CKD). Mechanisms underlying these abnormalities are complicated, and …

We have recently demonstrated that indoxyl sulfate promotes the progression of glomerular
sclerosis in uremic rats. In the present study, we determined whether an oral adsorbent (AST …