Development of targeted therapies in advanced gastric cancer: promising exploratory steps in a new era

AD Wagner, M Moehler - Current opinion in oncology, 2009 - journals.lww.com
Adequately powered, randomized phase III trials are necessary to define the clinical role of
targeted therapies in advanced gastric cancer. Biomarker studies to correlate with treatment …

A clinical viewpoint on the use of targeted therapy in advanced gastric cancer

M Skórzewska, K Gęca, WP Polkowski - Cancers, 2023 - mdpi.com
Simple Summary Outcomes for patients with advanced gastric cancer continue to be
unsatisfactory despite the inclusion of new targeted therapies in the treatment options. The …

The challenge of targeted therapies for gastric cancer patients: the beginning of a long journey

G Aprile, R Giampieri, M Bonotto, A Bittoni… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Despite significant improvements in systemic chemotherapy over the last two
decades, the prognosis of patients with advanced disease remains dismal. Collaborative …

[HTML][HTML] Chemotherapy for advanced gastric cancer: review and update of current practices

SC Park, HJ Chun - Gut and liver, 2013 - ncbi.nlm.nih.gov
No standard adjuvant or palliative chemotherapy regimen has been internationally
approved for patients with advanced gastric cancer. Adjuvant chemoradiotherapy is …

Targeted and novel therapy in advanced gastric cancer

JH Selim, S Shaheen, WC Sheu, CT Hsueh - Experimental Hematology & …, 2019 - Springer
The systemic treatment options for advanced gastric cancer (GC) have evolved rapidly in
recent years. We have reviewed the recent data of clinical trial incorporating targeted …

[HTML][HTML] Targeted therapy for advanced gastric cancer: A review of current status and future prospects

O Kanat, B O'Neil, S Shahda - World journal of gastrointestinal …, 2015 - ncbi.nlm.nih.gov
In the West in particular, the vast majority of gastric cancer (GC) patients present with
advanced-stage disease. Although combination chemotherapy is still the most important …

[HTML][HTML] Changing strategies for target therapy in gastric cancer

S Lee, SC Oh - World journal of gastroenterology, 2016 - ncbi.nlm.nih.gov
In spite of a worldwide decrease in the incidence of gastric cancer, this malignancy still
remains one of the leading causes of cancer mortality. Great efforts have been made to …

[HTML][HTML] Advanced gastric cancer: current treatment landscape and future perspectives

A Digklia, AD Wagner - World journal of gastroenterology, 2016 - ncbi.nlm.nih.gov
Gastric cancer currently ranks fourth in cancer-related mortality worldwide. In the western
world, it is most often diagnosed at an advanced stage, after becoming metastatic at distant …

Current molecular targeted therapy in advanced gastric cancer: A comprehensive review of therapeutic mechanism, clinical trials, and practical application

K Li, J Li - Gastroenterology research and practice, 2016 - Wiley Online Library
Despite the great progress in the treatment of gastric cancer, it is still the third leading cause
of cancer death worldwide. Patients often miss the opportunity for a surgical cure, because …

Novel targets in the treatment of advanced gastric cancer: a perspective review

E Fontana, EC Smyth - Therapeutic advances in medical …, 2016 - journals.sagepub.com
Gastric cancer is responsible for a high burden of disease globally. Although more extensive
use of chemotherapy together with the recent introduction of the two targeted agents …