Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic
iron homeostasis through its interaction with ferroportin, the major cellular iron export …

The fact that humans must balance their need for iron against its potential for causing harm
has been known for several centuries, but the molecular mechanisms by which we achieve …

The amount of iron in the plasma is determined by the regulated release of iron from most
body cells, but macrophages, intestinal enterocytes and hepatocytes play a particularly …

Hepcidin evolves as a potent hepatocyte‐derived regulator of the body's iron distribution
piloting the flow of iron via, and directly binding, to the cellular iron exporter ferroportin. The …

Systemic iron homeostasis depends on the regulated expression of hepcidin, a peptide
hormone that negatively regulates iron egress from intestinal cells and macrophages by …

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current
knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and …

Profound changes in iron metabolism occur in response to a variety of inflammatory stimuli.
Among the most important of these is the redistribution of body iron out of the circulation and …

Hepcidin is a key iron-regulatory hormone produced by the liver. Inappropriately low
hepcidin levels cause iron overload, while increased hepcidin expression plays an …

BACKGROUND: Hepcidin is a low-molecular weight hepatic peptide regulating iron
homeostasis. Hepcidin inhibits the cellular efflux of iron by binding to, and inducing the …

BACKGROUND The peptide hormone hepcidin plays a central role in regulating dietary iron
absorption and body iron distribution. Many human diseases are associated with alterations …