Safety, immunogenicity and efficacy of an mRNA-based COVID-19 vaccine, GLB-COV2-043, in preclinical animal models
F Lelis, LA Byk, S Pustylnikov, V Nguyen, B Nguyen… - Scientific Reports, 2023 - nature.com
Several COVID-19 vaccines, some more efficacious than others, are now available and
deployed, including multiple mRNA-and viral vector-based vaccines. With the focus on …
deployed, including multiple mRNA-and viral vector-based vaccines. With the focus on …
SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people
TM Narowski, K Raphel, LE Adams, J Huang, NA Vielot… - Cell reports, 2022 - cell.com
Understanding vaccine-mediated protection against severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) is critical to overcoming the global coronavirus disease 2019 …
coronavirus-2 (SARS-CoV-2) is critical to overcoming the global coronavirus disease 2019 …
Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …
[HTML][HTML] A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B. 1.1. 7) in a transmission-challenge hamster model
R Frise, L Baillon, J Zhou, R Kugathasan, TP Peacock… - Vaccine, 2022 - Elsevier
Vaccines for SARS-CoV-2 have been hugely successful in alleviating hospitalization and
deaths caused by the newly emerged coronavirus that is the cause of COVID. However …
deaths caused by the newly emerged coronavirus that is the cause of COVID. However …
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through …
S McCafferty, AKMA Haque, A Vandierendonck… - Molecular Therapy, 2022 - cell.com
Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at
lower doses compared to non-replicating mRNA vaccines via amplified antigen expression …
lower doses compared to non-replicating mRNA vaccines via amplified antigen expression …
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
R De Alwis, ES Gan, S Chen, YS Leong, HC Tan… - Molecular Therapy, 2021 - cell.com
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based …
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
Several vaccines have demonstrated efficacy against SARS-CoV-2 mediated disease, yet
there is limited data on the immune response induced by heterologous vaccination …
there is limited data on the immune response induced by heterologous vaccination …
SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys
KO Saunders, E Lee, R Parks, DR Martinez, D Li… - bioRxiv, 2021 - biorxiv.org
Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and
Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic …
Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic …
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) evolution has
resulted in many variants, contributing to the striking drop in vaccine efficacy and …
resulted in many variants, contributing to the striking drop in vaccine efficacy and …
[HTML][HTML] SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous …
DW Hawman, K Meade-White, J Archer, S Leventhal… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late-2021 with
resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants …
resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants …