Immunogenicity of low-dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

N van Doremalen, RJ Fischer, JE Schulz, MG Holbrook… - Viruses, 2021 - mdpi.com
Many different vaccine candidates against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the etiological agent of COVID-19, are currently approved and under …

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

W He, M Yuan, S Callaghan, R Musharrafieh… - Science translational …, 2022 - science.org
To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines
capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that …

[HTML][HTML] Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model

KV Kalnin, T Plitnik, M Kishko, D Huang, A Raillard… - Vaccine, 2022 - Elsevier
The emergence of SARS-CoV-2 variants, especially Beta and Delta, has raised concerns
about the reduced protection from previous infection or vaccination based on the original …

Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infection

JP Evans, C Zeng, C Carlin, G Lozanski… - Science Translational …, 2022 - science.org
The waning efficacy of SARS-CoV-2 vaccines, combined with the continued emergence of
variants resistant to vaccine-induced immunity, has reignited debate over the need for …

Cross-protective immunity following coronavirus vaccination and coronavirus infection

T Dangi, N Palacio, S Sanchez, M Park… - The Journal of …, 2021 - Am Soc Clin Investig
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have
shown efficacy against SARS-CoV-2, it is unknown if coronavirus vaccines can also protect …

Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates

V Pavot, C Berry, M Kishko, NG Anosova… - Nature …, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
that partly evade neutralizing antibodies raises concerns of reduced vaccine effectiveness …

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine

EZ Ong, JX Yee, JSG Ooi, A Syenina, R De Alwis… - npj Vaccines, 2022 - nature.com
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global
burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the …

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

PN Frantz, A Barinov, C Ruffié, C Combredet… - Nature …, 2021 - nature.com
Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic,
most of them based on messenger RNA or adenovirus vectors. The duration of protection …

SARS-CoV-2 mRNA vaccines elicit different responses in immunologically naïve and pre-immune humans

D Forgacs, H Jang, RB Abreu, HB Hanley… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic continues, the authorization of vaccines for emergency use has
been crucial in slowing down the rate of infection and transmission of the SARS-CoV-2 virus …

Long-term cross immune response in mice following heterologous prime-boost COVID-19 vaccination with full-length spike mRNA and recombinant S1 protein

D Li, H Zhao, Y Liao, G Jiang, P Cui, Y Zhang, L Yu… - Vaccines, 2023 - mdpi.com
(1) Background: As the COVID-19 pandemic enters its fourth year, it continues to cause
significant morbidity and mortality worldwide. Although various vaccines have been …