Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants

M Xing, Y Wang, X Wang, J Liu, W Dai, G Hu… - Journal of …, 2023 - Am Soc Microbiol
Developing broad-spectrum vaccines and optimal vaccination strategies is crucial to
controlling the COVID-19 pandemic. Here, we generated a chimpanzee adenoviral vector …

Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy

Y Wang, C Yang, Y Song… - Proceedings of the …, 2021 - National Acad Sciences
Successfully combating the COVID-19 pandemic depends on mass vaccination with suitable
vaccines to achieve herd immunity. Here, we describe COVI-VAC, the only live attenuated …

Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

H Zhao, TC Wang, XF Li, NN Zhang, L Li… - Signal transduction and …, 2021 - nature.com
Messenger RNA (mRNA) vaccine technology has shown its power in preventing the
ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of …

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - BioRxiv, 2020 - biorxiv.org
To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …

Oral Administration of universal bacterium-vectored nucleocapsid-expressing COVID-19 vaccine is efficacious in hamsters

Q Jia, H Bielefeldt-Ohmann, RM Maison… - Microbiology …, 2023 - Am Soc Microbiol
Oral delivery of an inexpensive COVID-19 (coronavirus disease 2019) vaccine could
dramatically improve immunization rates, especially in low-and middle-income countries …

Heterologous vaccination with inactivated vaccine and mRNA vaccine augments antibodies against both spike and nucleocapsid proteins of SARS-CoV-2: a local …

HM Ng, CL Lei, S Fu, E Li, SI Leong, CI Nip… - Frontiers in …, 2023 - frontiersin.org
The mRNA vaccines (RVs) can reduce the severity and mortality of severe acute respiratory
syndrome coronavirus (SARS-CoV-2). However, almost only the inactivated vaccines (IVs) …

Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters

Q Jia, H Bielefeldt-Ohmann, RM Maison… - npj Vaccines, 2021 - nature.com
To generate an inexpensive readily manufactured COVID-19 vaccine, we employed the LVS
Δ capB vector platform, previously used to generate potent candidate vaccines against …

Pre-existing SARS-CoV-2 immunity influences potency, breadth, and durability of the humoral response to SARS-CoV-2 vaccination

G Mantus, LE Nyhoff, VV Edara, VI Zarnitsyna… - Cell Reports …, 2022 - cell.com
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
highlights the importance of determining the breadth and durability of humoral immunity to …

Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history

TW McDade, AR Demonbreun, A Sancilio… - Scientific reports, 2021 - nature.com
Two-dose messenger RNA vaccines against the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are highly effective in preventing symptomatic COVID-19 …

Immunological evaluation of an inactivated SARS-CoV-2 vaccine in rhesus macaques

H Chen, Z Xie, R Long, S Fan, H Li, Z He, K Xu… - … Therapy-Methods & …, 2021 - cell.com
Because of the relatively limited understanding of coronavirus disease 2019 (COVID-19)
pathogenesis, immunological analysis for vaccine development is needed. Mice and …