Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …

Building on years of basic scientific discovery, recent advances in the fields of cancer
genetics and medicinal chemistry are now converging to revolutionize the treatment of …

Cancer therapeutics currently have the lowest clinical trial success rate of all major
diseases. Partly as a result of the paucity of successful anti-cancer drugs, cancer will soon …

In 2000, Hanahan and Weinberg [1] proposed that the remarkable diversity of neoplastic
diseases and of their underlying molecular mechanisms could be rationalized into six …

Trends in Molecular Medicine Vol. 8 No. 4 (Suppl.), 2002 Introduction| A TRENDS Guide to
Cancer Therapeutics also obvious. The pace and efficiency of drug discovery is accelerated …

Cancer is a disease of altered signaling and metabolism, causing uncontrolled division and
survival of transformed cells. A host of molecules, factors, and conditions have been …

In two landmark articles, Hanahan and Weinberg synthesized into one conceptual
framework 'the hallmarks of cancer', a massive amount of information describing the …

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Although all cancers share common hallmarks, we have long realized that there is no silver-
bullet treatment for the disease. Many clinical oncologists specialize in a single cancer type …

How cancer develops is no longer a mystery. During the past two decades, investigators
have made astonishing progress in identifying the deepest bases of the process—those at …