Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

[HTML][HTML] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies
and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal …

A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy

L Meng, J Zha, B Zhou, L Cao, C Jiang, Y Zhu… - PLoS …, 2023 - journals.plos.org
Neutralizing antibodies (nAbs) are important assets to fight COVID-19, but most existing
nAbs lose the activities against Omicron subvariants. Here, we report a human monoclonal …

Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA. 1-BA. 5

Y Wang, A Yan, D Song, C Dong, M Rao, Y Gao, R Qi… - Cell Discovery, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal
antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new …

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

P Ren, Y Hu, L Peng, L Yang, K Suzuki… - … and Targeted Therapy, 2023 - nature.com
SARS-CoV-2 rapidly evolves during the pandemic 1 with many variants of concern (VoCs)
lineages (Supplementary Fig. S1a). Omicron (B. 1.1. 529) and its sub-lineages led to …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron

S Wang, H Sun, Y Zhang, L Yuan, Y Wang, T Zhang… - Cell reports, 2022 - cell.com
The rapidly spreading Omicron variant is highly resistant to vaccines, convalescent sera,
and neutralizing antibodies (nAbs), highlighting the urgent need for potent therapeutic nAbs …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However,
the recent emergence of the Omicron variant has posed a challenge, as it evades detection …

B. 1.1. 529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes

Y Cao, J Wang, F Jian, T Xiao, W Song, A Yisimayi… - BioRxiv, 2021 - biorxiv.org
Abstract The SARS-CoV-2 B. 1.1. 529 variant (Omicron) contains 15 mutations on the
receptor-binding domain (RBD). How Omicron would evade RBD neutralizing antibodies …