Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by TrkC (∗)
M Rydén, CF Ibánez - Journal of Biological Chemistry, 1996 - ASBMB
Neurotrophins regulate differentiation and survival of vertebrate neurons through binding to
members of the Trk family of receptor tyrosine kinases and to a common low affinity receptor …
members of the Trk family of receptor tyrosine kinases and to a common low affinity receptor …
Functional analysis of mutant neurotrophins deficient in low‐affinity binding reveals a role for p75LNGFR in NT‐4 signalling.
The neurotrophins mediate their effects through binding to two classes of receptors, a
tyrosine kinase receptor, member of the Trk family, and the low‐affinity neurotrophin …
tyrosine kinase receptor, member of the Trk family, and the low‐affinity neurotrophin …
TrkA amino acids controlling specificity for nerve growth factor
L O'Connell, JA Hongo, LG Presta, P Tsoulfas - Journal of Biological …, 2000 - ASBMB
Neurotrophins are important for the development and maintenance of the vertebrate nervous
system, mediating their signal into the cell by specific interaction with tyrosine kinase …
system, mediating their signal into the cell by specific interaction with tyrosine kinase …
Structural Determinants of Neurotrophin Action (∗)
NQ McDonald, MV Chao - Journal of Biological Chemistry, 1995 - ASBMB
The neurotrophins represent a family of survival and differentiation factors that exert
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
We have exploited a battery of approaches to address several controversies that have
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors …
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors …
The binding epitopes of neurotrophin‐3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.
R Urfer, P Tsoulfas, D Soppet, E Escandon… - The EMBO …, 1994 - embopress.org
Survival and maintenance of vertebrate neurons are influenced by neurotrophic factors
which mediate their signal by binding to specific cell surface receptors. We determined the …
which mediate their signal by binding to specific cell surface receptors. We determined the …
[HTML][HTML] Heterodimeric neurotrophins induce phosphorylation of Trk receptors and promote neuronal differentiation in PC12 cells
JJS Treanor, C Schmelzer, B Knusel… - Journal of Biological …, 1995 - Elsevier
Neurotrophins are a family of highly conserved proteins that affect the development and
maintenance of distinct neuronal populations. Neurotrophins exist in vivo as homodimers …
maintenance of distinct neuronal populations. Neurotrophins exist in vivo as homodimers …
[HTML][HTML] Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
M Bibel, E Hoppe, YA Barde - The EMBO journal, 1999 - embopress.org
Neurotrophins bind to two structurally unrelated receptors, the trk tyrosine kinases and the
neurotrophin receptor p75 NTR. Ligand activation of these two types of receptor can lead to …
neurotrophin receptor p75 NTR. Ligand activation of these two types of receptor can lead to …
An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan‐neurotrophin.
CF Ibanez, LL Ilag, J Murray‐Rust, H Persson - The EMBO journal, 1993 - embopress.org
Neurotrophin‐mediated cell survival and differentiation of vertebrate neurons is caused by
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …
Structure–function relationships in the neurotrophin family
CF Ibáñez - Journal of neurobiology, 1994 - Wiley Online Library
The study of structure–function relationships in the neurotrophin family has in recent years
increased our understanding of several important aspects of neurotrophin function. Site …
increased our understanding of several important aspects of neurotrophin function. Site …