Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December …

Cellular and humoral immune responses in covid-19 and immunotherapeutic approaches

A Hasan, E Al-Ozairi, Z Al-Baqsumi… - ImmunoTargets and …, 2021 - Taylor & Francis
Abstract Coronavirus disease 2019 (Covid-19), caused by the novel coronavirus severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can range in severity from …

Role for anti-cytokine therapies in severe coronavirus disease 2019

LF Buckley, GF Wohlford, C Ting… - Critical care …, 2020 - journals.lww.com
Objectives: The causative agent for coronavirus disease 2019, severe acute respiratory
syndrome coronavirus 2, appears exceptional in its virulence and immunopathology. In …

Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

[HTML][HTML] Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …

Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
The exaggerated immune response induced in the lower respiratory tract against
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …

[PDF][PDF] Immunology of COVID-19: current state of the science

N Vabret, GJ Britton, C Gruber, S Hegde, J Kim… - Immunity, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …

[HTML][HTML] SARS-CoV-2: immune response elicited by infection and development of vaccines and treatments

G Canedo-Marroquin, F Saavedra… - Frontiers in …, 2020 - frontiersin.org
The World Health Organization (WHO) announced in March a pandemic caused by Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This new infectious disease was …

An enlightening role for cytokine storm in coronavirus infection

Z Zhao, Y Wei, C Tao - Clinical Immunology, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in Wuhan,
China has dispersed rapidly worldwide. Although most patients present with mild fever …

[HTML][HTML] Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19

RB Polidoro, RS Hagan, R de Santis Santiago… - Frontiers in …, 2020 - frontiersin.org
Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …