The functional importance of G protein-coupled receptor (GPCR) oligomerization remains
controversial. Although obligate dimers of class C GPCRs are well accepted, the …

G protein-coupled receptors (GPCRs) can exist as dimers or as larger oligomeric clusters
that enable intercommunication between different receptor protomers within the same …

Although the G protein-coupled receptor (GPCR) oligomerization has been questioned
during the last decade, under some premises the existence of a supramolecular …

G-protein-coupled receptors (GPCRs) represent by far the largest class of targets for modern
drugs. Virtually all therapeutics that are directed towards GPCRs have been designed using …

Although highly controversial just a few years ago, the idea that G‐protein‐coupled
receptors (GPCRs) may undergo homo‐oligomerization or hetero‐oligomerization has …

Allosteric regulation of ligand binding is a well-established mechanism regulating the
function of G protein-coupled receptors (GPCR). Allosteric modulators have been …

G protein‐coupled receptor (GPCR) oligomers are promising targets for the design of new
highly selective therapeutics. GPCRs have historically been attractive drug targets for their …

The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric
entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings …

As the largest family of cell surface receptors, G protein-coupled receptors (GPCRs)
represent an important strategic class of therapeutic targets. Attaining a clearer perspective …

The oligomerization of G protein-coupled receptors (GPCRs) is a fact that deserves further
attention as increases both the complexity and diversity of the receptor-mediated signal …