Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water
C Douillet, M Miller, PH Cable, Q Shi, H El-Masri… - Scientific Reports, 2023 - nature.com
Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher
rates of iAs methylation in mice than in humans may limit their utility as a model organism. A …
rates of iAs methylation in mice than in humans may limit their utility as a model organism. A …
Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement
BH Koller, JN Snouwaert, C Douillet… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health
problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification …
problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification …
Metabolomic profiles of arsenic (+ 3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure
MC Huang, C Douillet, M Su, K Zhou, T Wu… - Archives of …, 2017 - Springer
Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) is the key enzyme in the
pathway for methylation of inorganic arsenic (iAs). Altered As3mt expression and AS3MT …
pathway for methylation of inorganic arsenic (iAs). Altered As3mt expression and AS3MT …
Mouse arsenic (+ 3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water
Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …
Dose-dependent urinary phenotype of inorganic arsenic methylation in mice with a focus on trivalent methylated metabolites
EA García-Montalvo, OL Valenzuela… - Toxicology …, 2011 - Taylor & Francis
Inorganic arsenic (iAs) exposure has been associated with the increased risk of various
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …
Arsenic (+ 3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice
MF Hughes, BC Edwards, KM Herbin-Davis… - Toxicology and applied …, 2010 - Elsevier
Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes formation of mono-, di-,
and tri-methylated metabolites of inorganic arsenic. Distribution and retention of arsenic …
and tri-methylated metabolites of inorganic arsenic. Distribution and retention of arsenic …
[HTML][HTML] Arsenite Methyltransferase Is an Important Mediator of Hematotoxicity Induced by Arsenic in Drinking Water
S Medina, H Zhang, LV Santos-Medina, ZA Yee… - Water, 2023 - mdpi.com
Chronic arsenic exposures via the consumption of contaminated drinking water are clearly
associated with many deleterious health outcomes, including anemia. Following exposure …
associated with many deleterious health outcomes, including anemia. Following exposure …
Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+ 3 oxidation state) methyltransferase-knockout mice
JM Currier, C Douillet, Z Drobná, M Stýblo - Journal of Environmental …, 2016 - Elsevier
Arsenic methyltransferase (As3mt) catalyzes the conversion of inorganic arsenic (iAs) to its
methylated metabolites, including toxic methylarsonite (MAs III) and dimethylarsinite (DMAs …
methylated metabolites, including toxic methylarsonite (MAs III) and dimethylarsinite (DMAs …
Knockout of arsenic (+ 3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure
C Douillet, MC Huang, RJ Saunders, EN Dover… - Archives of …, 2017 - Springer
Susceptibility to toxic effects of inorganic arsenic (iAs) depends, in part, on efficiency of iAs
methylation by arsenic (+ 3 oxidation state) methyltransferase (AS3MT). As3mt-knockout …
methylation by arsenic (+ 3 oxidation state) methyltransferase (AS3MT). As3mt-knockout …
Disruption of the arsenic (+ 3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention …
Z Drobna, H Naranmandura… - Chemical research in …, 2009 - ACS Publications
The arsenic (+ 3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …