Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation

KH Weylandt, CY Chiu, B Gomolka… - Prostaglandins & other …, 2012 - Elsevier
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have long been associated with
decreased inflammation and are also implicated in the prevention of tumorigenesis …

Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

H Seki, Y Tani, M Arita - Prostaglandins & other lipid mediators, 2009 - Elsevier
Inflammation is a defensive response to injury and infection, but excessive or inappropriate
inflammation contributes to a range of acute and chronic human diseases. Clinical …

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers

CN Serhan, M Arita, S Hong, K Gotlinger - Lipids, 2004 - Springer
The molecular basis for the beneficial impact of essential omega-3 (n− 3) FA remains of
interest. Recently, we identified novel mediators generated from eicosapentaenoic acid …

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective …

CN Serhan, K Gotlinger, S Hong, M Arita - Prostaglandins & other lipid …, 2004 - Elsevier
The molecular basis for the beneficial impact of essential omega-3 fatty acids is of
considerable interest. Recently, novel mediators generated from eicosapentaenoic acid …

Docosapentaenoic acid derived metabolites and mediators–the new world of lipid mediator medicine in a nutshell

KH Weylandt - European journal of pharmacology, 2016 - Elsevier
Recent years have seen the description and elucidation of a new class of anti-inflammatory
and pro-resolving lipid mediators. The arachidonic acid (AA)-derived compounds in this …

Polyunsaturated fatty acids and inflammatory processes: new twists in an old tale

PC Calder - Biochimie, 2009 - Elsevier
The n-6 fatty acid arachidonic acid (AA; 20: 4n-6) gives rise to eicosanoid mediators that
have established roles in inflammation and AA metabolism is a long recognised target for …

[HTML][HTML] Significance of long chain polyunsaturated fatty acids in human health

R Zárate, N el Jaber-Vazdekis, N Tejera… - Clinical and translational …, 2017 - Springer
In the last decades, the development of new technologies applied to lipidomics has
revitalized the analysis of lipid profile alterations and the understanding of the underlying …

Eicosapentaenoic and docosahexaenoic acid derived specialised pro-resolving mediators: Concentrations in humans and the effects of age, sex, disease and …

PC Calder - Biochimie, 2020 - Elsevier
Although inflammation has a physiological role, unrestrained inflammation can be
detrimental, causing tissue damage and disease. Under normal circumstances inflammation …

Resolvins and protectins: mediating solutions to inflammation

P Kohli, BD Levy - British journal of pharmacology, 2009 - Wiley Online Library
Resolution of inflammation has historically been viewed as a passive process, occurring as
a result of the withdrawal of pro‐inflammatory signals, including lipid mediators such as …

Novel chemical mediators in the resolution of inflammation: resolvins and protectins

CN Serhan - Anesthesiology Clinics of North America, 2006 - anesthesiology.theclinics.com
The molecular basis for the beneficial impact of omega-3 fatty acids eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) remains of interest. Recently, the author's …