Background Colon cancer is the third most common cancer in the world, and its metastasis
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …

ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …

Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however,
the underlying mechanisms of CRC remain largely unknown. New evidence suggests that …

In the last decade, pathway-specific targeted therapy has revolutionized colorectal cancer
(CRC) treatment strategies. This type of therapy targets a tumor-vulnerable spot formed …

The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers,
including colon cancer, making it a promising treatment target. This study aims to investigate …

Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …

Abstract Purpose The phosphoinositide-3-kinase (PI3K) pathway is the frequently altered in
human cancer. This has led to the development and study of novel PI3K inhibitors for …

Colorectal cancer is one of the most common malignancies in the world. Overactivity of
phosphatidylinositol 3-kinase (PI3K) is frequently detected in colorectal carcinoma. PI3K …