Several critical cell functions are influenced not only by internal cellular machinery but also
by external mechanical and biochemical cues from the surrounding microenvironment …

Mechanical properties of cells can be correlated with various cell states and are now
considered as an important class of biophysical markers. Effectiveness of existing high …

The major characteristics of cancer metastasis is the ability of the primary tumor cells to
migrate by way of the blood or lymph vessels and to form tumors at multiple, distant sites …

Editorial Babahosseini, Strobl & Agah screening of therapeutic agents that target
cytoskeleton dysfunction. One application of this approach is the determination whether the …

We have developed animal models of breast cancer that allow the direct examination of the
behavior of individual green fluorescent protein-expressing carcinoma cells in live …

Cell deformability is a label-free biomarker of cell state in physiological and disease contexts
ranging from stem cell differentiation to cancer progression. Harnessing deformability as a …

Disease can induce changes to subcellular components, altering cell phenotype and
leading to measurable bulk-material mechanical properties. The mechanical phenotyping of …

While it has been established that a number of microenvironment components can affect the
likelihood of metastasis, the link between microenvironment and tumor cell phenotypes is …

Cell deformability is a well-established marker of cell states for diagnostic purposes.
However, the measurement of a wide range of different deformability levels is still …

A hallmark of metastatic cancer cells is their invasion through the basal membrane and
endothelial layer, which requires a highly elastic cytoskeleton and nucleus. Therefore …