Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

M Alegría-Arcos, T Barbosa, F Sepúlveda… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 pandemic accelerated drug/vaccine development processes,
integrating scientists all over the globe to create therapeutic alternatives against this virus. In …

A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing

M Habibi, G Taheri, R Aghdam - Scientific reports, 2021 - nature.com
Abstract The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus
needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding …

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

X Liu, S Huuskonen, T Laitinen, T Redchuk… - Molecular Systems …, 2021 - embopress.org
Abstract Treatment options for COVID‐19, caused by SARS‐CoV‐2, remain limited.
Understanding viral pathogenesis at the molecular level is critical to develop effective …

Network analytics for drug repurposing in COVID-19

N Siminea, V Popescu… - Briefings in …, 2022 - academic.oup.com
To better understand the potential of drug repurposing in COVID-19, we analyzed control
strategies over essential host factors for SARS-CoV-2 infection. We constructed …

Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2

RK Singh, BS Yadav, TM Mohapatra - Bulletin of the National Research …, 2020 - Springer
Background COVID-19, a pandemic declared by WHO, has infected about 39.5 million and
killed about 1.1 million people throughout the world. There is the urgent need of more …

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

S Sadegh, J Matschinske, DB Blumenthal… - Nature …, 2020 - nature.com
Abstract Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the
SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection …

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

A Samy, MA Maher, NA Abdelsalam, E Badr - Scientific Reports, 2022 - nature.com
COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus
evolve, a complete comprehension of the disease and drug targets becomes a decisive …

[HTML][HTML] Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches

G Selvaraj, S Kaliamurthi, GH Peslherbe… - F1000Research, 2021 - ncbi.nlm.nih.gov
Background: Coronavirus (CoV) is an emerging human pathogen causing severe acute
respiratory syndrome (SARS) around the world. Earlier identification of biomarkers for SARS …

Ontological and bioinformatic analysis of anti-coronavirus drugs and their implication for drug repurposing against COVID-19

Y Liu, W Chan, Z Wang, J Hur, J Xie, H Yu, Y He - 2020 - preprints.org
Coronavirus-infected diseases have posed great threats to human health. In past years,
highly infectious coronavirus-induced diseases, including COVID-19, SARS, and MERS …

[HTML][HTML] Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome

MS Bogacheva, S Kuivanen, S Potdar, A Hassinen… - Antiviral Research, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the
global healthcare system. Despite the vaccination programs, the new virus variants are …