Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to
ensure sufficient exposure for clinical activity while minimizing toxicity. These agents …

Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of
antibiotics, immunosuppressives, antiepileptics, and other drugs, but its use for traditional …

Pharmacology and Therapeutics (Figure 1) provides a tour of selected innovations in
precision medicine, model-informed drug discovery and development frameworks, and the …

Purpose Given the toxic nature and narrow therapeutic index of traditional
chemotherapeutics, better methods of dose and therapy selection are critical …

Over the last 10 years, proofs of the clinical interest of therapeutic drug monitoring (TDM) of
certain anticancer drugs have been established. Numerous studies have shown that TDM is …

In the modern era of cancer treatment, with targeted agents superseding more traditional
cytotoxic chemotherapeutics, it is becoming increasingly important to use stratified medicine …

Precision medicine characterizes a new era of cancer care and provides each patient with
the right drug at the right dose and time. However, the practice of precision dosing is …

Background: Anticancer drugs are characterized by a narrow therapeutic window and
significant inter-patient variability in therapeutic and toxic effects. Current body surface area …

Background Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely
determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied …

Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …