Herbal medicines for ischemic stroke: combating inflammation as therapeutic targets

Y Gu, J Chen, J Shen - Journal of Neuroimmune Pharmacology, 2014 - Springer
Stroke is a debilitating disease for which limited therapeutic approaches are available
currently. Thus, there is an urgent need for developing novel therapies for stroke. Astrocytes …

Anti‐Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia

CY Cheng, YC Lee - Evidence‐Based Complementary and …, 2016 - Wiley Online Library
Inflammation plays a crucial role in the pathophysiology of acute ischemic stroke. In the
ischemic cascade, resident microglia are rapidly activated in the brain parenchyma and …

Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

B Zhang, KE Saatman, L Chen - Neural regeneration research, 2020 - journals.lww.com
Stroke is one of the leading causes of death and disability in adults worldwide, resulting in
huge social and financial burdens. Extracts from herbs, especially those used in Chinese …

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

W Zhang, H Xu, C Li, B Han, Y Zhang - Frontiers in pharmacology, 2024 - frontiersin.org
Ischemic stroke is a prevalent clinical condition affecting the central nervous system,
characterized by a high mortality and disability rate. Its incidence is progressively rising …

[HTML][HTML] Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs

T Zhu, L Wang, L Wang, Q Wan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug …

T Peng, Y Jiang, M Farhan, P Lazarovici… - Frontiers in …, 2019 - frontiersin.org
Acquired brain ischemia-and reperfusion-injury (IRI), including both Ischemic stroke (IS) and
Traumatic Brain injury (TBI), is one of the most common causes of disability and death in …

[HTML][HTML] Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective

T Tao, M Liu, M Chen, Y Luo, C Wang, T Xu… - Pharmacology & …, 2020 - Elsevier
There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

Natural herbal extract roles and mechanisms in treating cerebral ischemia: A systematic review

J Yang, B Yu, J Zheng - Frontiers in Pharmacology, 2024 - frontiersin.org
Background Stroke has been the focus of medical research due to its serious consequences
and sequelae. Among the tens of millions of new stroke patients every year, cerebral …

Neuroprotective effect for cerebral ischemia by natural products: A review

Q Xie, H Li, D Lu, J Yuan, R Ma, J Li, M Ren… - Frontiers in …, 2021 - frontiersin.org
Natural products have a significant role in the prevention of disease and boosting of health
in humans and animals. Stroke is a disease with high prevalence and incidence, the …

[HTML][HTML] Flavonoids and ischemic stroke-induced neuroinflammation: focus on the glial cells

W Lu, Z Chen, J Wen - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality.
In the pathological process of ischemic stroke, neuroinflammation is an essential process …