Genetics of cancer therapy-associated cardiotoxicity

Y Kim, JG Seidman, CE Seidman - Journal of molecular and cellular …, 2022 - Elsevier
As the number of cancer survivors has increased significantly over the last decades due to
aging of population and development of effective cancer therapies, side effects from cancer …

Preclinical models of cancer therapy–associated cardiovascular toxicity: a scientific statement from the American heart association

A Asnani, JJ Moslehi, BB Adhikari, AH Baik… - Circulation …, 2021 - Am Heart Assoc
Although cardiovascular toxicity from traditional chemotherapies has been well recognized
for decades, the recent explosion of effective novel targeted cancer therapies with …

Possible Susceptibility Genes for Intervention against Chemotherapy‐Induced Cardiotoxicity

X Yang, G Li, T Yang, M Guan, N An… - Oxidative Medicine …, 2020 - Wiley Online Library
Recent therapeutic advances have significantly improved the short‐and long‐term survival
rates in patients with heart disease and cancer. Survival in cancer patients may, however, be …

Genetic Predisposition to Cardiovascular Disease in Patients With Cancer: A Clinical Perspective

D Farmakis, G Papingiotis, G Filippatos - Cardio Oncology, 2023 - jacc.org
Baseline risk stratification for cardiotoxicity is a crucial component of the cardio-oncology
service. 1, 2 Guideline statements recommend risk assessment based on a number of …

Anticancer drug-induced cardiotoxicity: insights and pharmacogenetics

A Adhikari, SMB Asdaq, MA Al Hawaj, M Chakraborty… - Pharmaceuticals, 2021 - mdpi.com
The advancement in therapy has provided a dramatic improvement in the rate of recovery
among cancer patients. However, this improved survival is also associated with enhanced …

Cardiotoxicity of anticancer drugs: Molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications

C Kwok, M Nolan - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Cardio-oncology is an emerging field that seeks to enhance quality of life and longevity of
cancer survivors. It is pertinent for clinicians to understand the cellular mechanisms of …

Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity

CK Glass, RN Mitchell - Cardiovascular Pathology, 2017 - Elsevier
Abstract In the United States, the lifetime risk of a cancer diagnosis is nearly 40%; in 2016,
that represents almost 1.6 million new patients, and despite advances in early diagnosis and …

Cardiac complications of cancer therapies

AG Mauro, K Hunter, FN Salloum - Advances in cancer research, 2022 - Elsevier
The quest of defeating cancer and improving prognosis in survivors has generated
remarkable strides forward in research and have advanced the development of new …

Mechanisms and genetic susceptibility of chemotherapy-induced cardiotoxicity in patients with breast cancer

DJ Mihalcea, M Florescu… - American Journal of …, 2017 - journals.lww.com
Background: Cardiotoxicity remains an important adverse reaction of chemotherapy used in
the treatment of breast cancer, leading to increased morbidity and mortality. Data Sources …