Gout is the most common form of inflammatory arthritis. It occurs when monosodium urate
crystals (MSU) are deposited within joints due to hyperuricemia and persistent elevations of …

Gouty arthritis is characterized by the precipitation of monosodium urate (MSU) crystals in
the joint. Pro-inflammatory cytokine IL-1β is a critical manifestation in response to MSU …

Abstract The NACHT, LRR, and PYD-domains-containing protein 3 (NLRP3) inflammasome
is an intracellular multi-protein signaling platform that is activated by cytosolic pattern …

Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

The NLRP3 inflammasome is implicated in the processing of the pro-inflammatory cytokine
interleukin 1β. Inflammatory disorders associated with the activation of the NLRP3 …

Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the
precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to …

Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of
NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. The NLRP3 …

Activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome
plays a crucial role in the inflammatory responses of monosodium urate (MSU) crystal …

Background Since NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors
could be employed as therapeutic agents against gout, a representative disease caused by …

Objective The aetiology of gout is closely linked to the deposition of monosodium uric acid
(MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain …