The relationship between mdm2 gene expression and p53 gene mutation in hepatocellular
carcinoma (HCC) and their correlation with the invasiveness of the disease were …

Background/Aims: The transcription of mdm2 gene is activated by p53 and this limits the
growth‐suppressing activity of p53 by direct binding. It has been reported that MDM2 protein …

Aberration of the p53 gene is thought to be the most frequent genetic alteration in human
cancers. Tp53 protein may be inactivated by the binding of the MDM2 protein. MDM2, the …

In the present study, the expression of P53 and MDM2 proteins were examined in
specimens from a group of 20 patients (9 with primary hepatocellular carcinoma HCC and …

MDM2 and MDM4, a structurally related MDM2 homolog, negatively regulates expression
and functions of TP53 tumor suppressor gene. To explore the precise expression patterns …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

The tumor suppressor p53 is inactivated by overexpression of MDM2 in about 10% of
human tumors. However, p53 is inactivated by other mechanisms in the majority of tumors …

The Mdm2 gene is overexpressed in several human tumors. The oncogenic potential of
Mdm2 is partially explained by the inhibition of the activity of the tumor suppressor protein …

Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and
negative regulator of p53, are commonly observed in cancers. The MDM2–p53 feedback …

The ability of Mdm2 to inhibit the activities of a C-terminal truncated p53 mutant, p53-Δ30,
which can bind Mdm2 but is resistant to Mdm2-mediated protein degradation was …