Concordance and predictive value of two adverse drug event data sets

A Cami, BY Reis - BMC Medical Informatics and Decision Making, 2014 - Springer
Background Accurate prediction of adverse drug events (ADEs) is an important means of
controlling and reducing drug-related morbidity and mortality. Since no single “gold …

[HTML][HTML] ADEpedia 2.0: integration of normalized adverse drug events (ADEs) knowledge from the UMLS

G Jiang, H Liu, HR Solbrig… - AMIA Summits on …, 2013 - ncbi.nlm.nih.gov
Abstract A standardized Adverse Drug Events (ADEs) knowledge base that encodes known
ADE knowledge can be very useful in improving ADE detection for drug safety surveillance …

Exploring adverse drug events at the class level

R Winnenburg, A Sorbello, O Bodenreider - Journal of Biomedical …, 2015 - Springer
Background While the association between a drug and an adverse event (ADE) is generally
detected at the level of individual drugs, ADEs are often discussed at the class level, ie, at …

CT-ADE: An Evaluation Benchmark for Adverse Drug Event Prediction from Clinical Trial Results

A Yazdani, A Bornet, B Zhang, P Khlebnikov… - arXiv preprint arXiv …, 2024 - arxiv.org
Adverse drug events (ADEs) significantly impact clinical research and public health,
contributing to failures in clinical trials and leading to increased healthcare costs. The …

Clinical prediction rule to identify high‐risk inpatients for adverse drug events: the JADE Study

M Sakuma, DW Bates… - … and drug safety, 2012 - Wiley Online Library
ABSTRACT Purpose Adverse drug events (ADEs) are common health problems worldwide.
Developing a prediction rule to identify patients at high risk for ADEs to prevent or ameliorate …

Predicting adverse drug events using pharmacological network models

A Cami, A Arnold, S Manzi, B Reis - Science translational medicine, 2011 - science.org
Early and accurate identification of adverse drug events (ADEs) is critically important for
public health. We have developed a novel approach for predicting ADEs, called predictive …

Drug-versus-drug adverse event rate comparisons: a pilot study based on data from the US FDA Adverse Event Reporting System

AM Hochberg, RK Pearson, DJ O'Hara, SJ Reisinger - Drug safety, 2009 - Springer
Background: A number of published studies compare adverse event rates for drugs on the
basis of reports in the US FDA Adverse Event Reporting System (AERS). While the AERS …

Novel data‐mining methodologies for adverse drug event discovery and analysis

R Harpaz, W DuMouchel, NH Shah… - Clinical …, 2012 - Wiley Online Library
An important goal of the health system is to identify new adverse drug events (ADEs) in the
postapproval period. Data‐mining methods that can transform data into meaningful …

Calculating a Severity Score of an Adverse Drug Event Using Machine Learning on the FAERS Database

RP Schumaker, MA Veronin, RR Dixit… - IIMA/ICITED UWS …, 2017 - scholar.archive.org
An Adverse Drug Event (ADE) is medical injury that can result from a prescription or over the
counter drug that causes an allergic reaction, overdose, reaction with other drugs or is the …

Machine-learning-based adverse drug event prediction from observational health data: A review

J Denck, E Ozkirimli, K Wang - Drug Discovery Today, 2023 - Elsevier
Adverse drug events (ADEs) are responsible for a significant number of hospital admissions
and fatalities. Machine learning models have been developed to assess individual patient …