Prevention of noise-induced hearing loss using investigational medicines for the inner ear: Previous trial outcomes should inform future trial design

CG Le Prell - Antioxidants & redox signaling, 2022 - liebertpub.com
Significance: Noise-induced hearing loss (NIHL) is an important public health issue resulting
in decreased quality of life for affected individuals, and significant costs to employers and …

Emerging therapeutic interventions against noise-induced hearing loss

SH Sha, J Schacht - Expert opinion on investigational drugs, 2017 - Taylor & Francis
Introduction: Noise-induced hearing loss (NIHL) due to industrial, military, and recreational
noise exposure is a major, but also potentially preventable cause of acquired hearing loss …

Strategies for evaluating antioxidant efficacy in clinical trials assessing prevention of noise-induced hearing loss

CG Le Prell, E Lobarinas - Free Radicals in ENT Pathology, 2015 - Springer
Outcomes in studies assessing the prevention of acquired hearing loss have been
encouraging, particularly with respect to the prevention of noise-induced hearing loss (NIHL) …

Emerging treatments for noise-induced hearing loss

N Oishi, J Schacht - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Approximately 5% of the population worldwide suffers from industrial, military or
recreational noise-induced hearing loss (NIHL) at a great economic cost and detriment to …

Pharmacological prevention of noise-induced hearing loss: a systematic review

A Gupta, S Koochakzadeh, SA Nguyen… - Otology & …, 2021 - journals.lww.com
Pharmacological Prevention of Noise-induced Hearing Loss: A... : Otology & Neurotology
Pharmacological Prevention of Noise-induced Hearing Loss: A Systematic Review : Otology & …

[HTML][HTML] Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

FJ Santaolalla Sanchez, JD Gutierrez Posso… - Antioxidants, 2024 - mdpi.com
Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on
cognition, quality of life and work, social relationships, motor skills, and other psychological …

Octave band noise exposure: Laboratory models and otoprotection efforts

SN Gittleman, CG Le Prell, TL Hammill - The Journal of the Acoustical …, 2019 - pubs.aip.org
With advances in the understanding of mechanisms of noise injury, the past 30 years have
brought numerous efforts to identify drugs that prevent noise-induced hearing loss (NIHL) …

Prevention of noise-induced hearing loss: potential therapeutic agents

CG Le Prell, J Bao - Noise-induced hearing loss: Scientific advances, 2012 - Springer
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. The
development of novel therapeutic agents to reduce NIHL would increase the potential …

Compounds for the prevention and treatment of noise-induced hearing loss

ED Lynch, J Kil - Drug discovery today, 2005 - Elsevier
Noise-induced hearing loss (NIHL) is the leading occupational disease and a major
contributor to the development of age-related hearing loss. The pharmacological prevention …

Noise-induced hearing loss

N Natarajan, S Batts, KM Stankovic - Journal of clinical medicine, 2023 - mdpi.com
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural
hearing loss, after age-related hearing loss, and affects approximately 5% of the world's …