Unraveling determinants of transcription factor binding outside the core binding site
Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control
of gene expression. Despite many advances in the characterization of sequence motifs …
of gene expression. Despite many advances in the characterization of sequence motifs …
Transcription factors: specific DNA binding and specific gene regulation
Specific recognition of cis-regulatory regions is essential for correct gene regulation in
response to developmental and environmental signals. Such DNA sequences are …
response to developmental and environmental signals. Such DNA sequences are …
The functional consequences of variation in transcription factor binding
One goal of human genetics is to understand how the information for precise and dynamic
gene expression programs is encoded in the genome. The interactions of transcription …
gene expression programs is encoded in the genome. The interactions of transcription …
Transcription factor trapping by RNA in gene regulatory elements
Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …
elements to regulate gene transcription. RNA is transcribed from both of these DNA …
Determination and inference of eukaryotic transcription factor sequence specificity
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
Principles of regulatory information conservation between mouse and human
To broaden our understanding of the evolution of gene regulation mechanisms, we
generated occupancy profiles for 34 orthologous transcription factors (TFs) in human …
generated occupancy profiles for 34 orthologous transcription factors (TFs) in human …
Sequence features that drive human promoter function and tissue specificity
JM Landolin, DS Johnson, ND Trinklein… - Genome …, 2010 - genome.cshlp.org
Promoters are important regulatory elements that contain the necessary sequence features
for cells to initiate transcription. To functionally characterize a large set of human promoters …
for cells to initiate transcription. To functionally characterize a large set of human promoters …
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression
A complex interplay between transcription factors (TFs) and the genome regulates
transcription. However, connecting variation in genome sequence with variation in TF …
transcription. However, connecting variation in genome sequence with variation in TF …
Generic binding sites, generic DNA‐binding domains: where does specific promoter recognition come from?
A transcription reaction relies on the specific recognition of cis‐regulatory regions containing
short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the …
short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the …
On the relation between promoter divergence and gene expression evolution
I Tirosh, A Weinberger, D Bezalel… - Molecular Systems …, 2008 - embopress.org
Recent studies have characterized significant differences in the cis‐regulatory sequences of
related organisms, but the impact of these differences on gene expression remains largely …
related organisms, but the impact of these differences on gene expression remains largely …