Statistical models have been used to quantify the relationship between gene expression and
transcription factor (TF) binding signals. Here we apply the models to the large-scale data …

Abstract TFClass (http://tfclass. bioinf. med. uni-goettingen. de/) provides a comprehensive
classification of human transcription factors based on their DNA-binding domains …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Transcription factor (TF) binding specificities (motifs) are essential for the analysis of gene
regulation. Accurate prediction of TF motifs is critical, because it is infeasible to assay all TFs …

Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of
genes; the ensemble of these binding events forms a regulatory network, constituting the …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

The initiation of transcription is regulated by transcription factors (TFs) binding to DNA
response elements (REs). How do TFs recognize specific binding sites among the many …

Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …

Gene promoters typically contain multiple transcription factor binding sites (TFBSs), which
may vary in affinity for their cognate transcription factors (TFs). One major challenge in …