Design, synthesis, docking, and antiviral evaluation of some novel pyrimidinone-based α-aminophosphonates as potent H1N1 and HCoV-229E inhibitors

HA Hekal, OM Hammad, NR El-Brollosy, MM Salem… - Bioorganic …, 2024 - Elsevier
Abstract Dialkyl/aryl aminophosphonates, 3a-g and 4a-e were synthesized using the LiClO 4
catalyzed Kabachnic Fields-type reaction straightforwardly and efficiently. The synthesized …

Green synthesis, antibacterial, antiviral and molecular docking studies of α-aminophosphonates

S Poola, S Nagaripati, S Tellamekala… - Synthetic …, 2020 - Taylor & Francis
An efficient method for the synthesis of α-aminophosphonate derivatives has been
developed with different functional groups under catalyst and solvent free conditions at room …

Discovery of Novel α-Aminophosphonates with Hydrazone as Potential Antiviral Agents Combined With Active Fragment and Molecular Docking

J Tian, R Ji, H Wang, S Li, G Zhang - Frontiers in Chemistry, 2022 - frontiersin.org
A series of novel α-aminophosphonate derivatives containing hydrazone were designed
and synthesized based on active fragments. Bioassay results demonstrated that title …

2‐Amino‐3‐cyano‐4H‐chromene‐4‐ylphosphonates as potential antiviral agents: Synthesis, in ovo and in silico approach

MS Shaik, MR Nadiveedhi, M Gundluru… - Journal of …, 2021 - Wiley Online Library
A simplistic synthetic procedure for the synthesis of structurally diversified 2‐amino‐3‐cyano‐
4H‐chromene‐4‐ylphosphonates (4a‐j) were developed by the treatment of substituted …

Design, synthesis and molecular modeling studies of novel 2-quinolone-1, 2, 3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents

K El Gadali, M Rafya, M Maatallah, A Vanderlee… - European Journal of …, 2024 - Elsevier
With the aim to identify new antiviral agents with antibacterial properties, a series of 2-
quinolone-1, 2, 3-triazole derivatives bearing α-aminophosphonates was synthesized and …

Synthesis of Novel 1,3,4-Oxadiazole-Derived α-Aminophosphonates/α-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian …

S Hkiri, M Mekni-Toujani, E Üstün, K Hosni, A Ghram… - Pharmaceutics, 2022 - mdpi.com
An efficient and simple approach has been developed for the synthesis of eight dialkyl/aryl
[(5-phenyl-1, 3, 4-oxadiazol-2-ylamino)(aryl) methyl] phosphonates through the Pudovik …

Design, synthesis, and anti-TMV bioactivities of nucleobase phosphonate analogs

ZX Li, HS Fang, WB Shao, PY Wang… - … , Sulfur, and Silicon …, 2017 - Taylor & Francis
ABSTRACT A series of novel nucleobase derivatives and their analogues possessing
diethoxyphosphoryl scaffolds were synthesized through four-step reactions and screened for …

Hydrazineylidene‐3‐oxopropanal derivatives as antiviral agents for treatment of HBV and HCV: experimental, DFT, and molecular docking studies

I Benjamin, H Louis, AD Udoikono… - Vietnam Journal of …, 2023 - Wiley Online Library
In this study, two derivatives of hydrazineylidene‐3‐oxopropanal: chlorophenyl (CPHO) and
Nitrophenyl (NPHO) substituted hydrazineylidene compounds were synthesized …

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 4‐[4‐Arylpyridin‐1(4H)‐yl]benzoic Acid Derivatives as Anti‐HIV‐1 Agents

S Sepehri, S Soleymani, R Zabihollahi… - Chemistry & …, 2017 - Wiley Online Library
The structural similarities between N1 substituted 1, 4‐dihydropyridines and the known gp41
inhibitors, NB‐2 and NB‐64, were considered in the current research for the design of some …

Novel biphenyl derivatives with α-aminophosphonate moiety: Design, synthesis and antivirus activity

GP Zhang, M Liu - Letters in Drug Design & Discovery, 2016 - ingentaconnect.com
A series of novel biphenyl derivatives with α-aminophosphonate moiety was designed and
successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The …